Depo-Provera is a hormonal contraceptive injection intended to provide long-term birth control for women. Though it was widely promoted as a convenient and effective form of contraception, troubling side effects and long-term health risks have led to a growing number of lawsuits against the drug’s manufacturer, Pfizer.
After using Depo-Provera many women were later diagnosed with meningiomas, complications they claim were never adequately disclosed. If you or someone you love has experienced life-altering side effects after using Depo-Provera, the Depo-Provera lawyers at Constant Legal Group are here to help.
What Is Depo-Provera?
Depo-Provera is a brand name for the injectable form of medroxyprogesterone acetate, a synthetic hormone that also goes by the name depot medroxyprogesterone acetate. It’s administered as a shot every three months and has been marketed as a safe, long-acting form of birth control. However, serious questions have been raised about the drug’s safety, particularly for long-term users.
Depo-Provera works by suppressing ovulation (it stops the ovaries from releasing an egg), thickening cervical mucus, and thinning the uterine lining to prevent pregnancy. It largely tries to keep sperm from reaching the egg. It’s been approved by the FDA for use since the early 1990s, but concerns about its risks have grown significantly in recent years.

Why Is There a Depo-Provera Lawsuit?
The lawsuits surrounding Depo-Provera focus primarily on claims that the drug’s manufacturer failed to adequately warn users about serious risks, including brain tumors or meningiomas.
Plaintiffs allege that if they had been properly warned of these risks, they would have chosen a different method of contraception.
In 2004, the FDA required a “black box” warning for Depo-Provera to address the risk of significant bone density loss. However, the warning failed to mention anything regarding the possibility of developing a brain tumor. The FDA warning on Depo-Provera also states that the medicine shouldn’t be used for longer than two years.
According to the Mayo Clinic, some of the other side effects of Depo-Provera include:
- Belly pain.
- Bloating.
- Less interest in sex.
- Depression.
- Dizziness.
- Headaches.
- Irregular periods and breakthrough bleeding.
- Nervousness.
- Weakness and tiredness.
- Weight gain.
The Legal Claims Against Depo-Provera
The core legal issue in these cases is failure to warn. Drug manufacturers have a duty to inform consumers and healthcare providers of all known and reasonably knowable risks. When companies prioritize profits over patient safety, the consequences can be devastating.
Claimants may be eligible to file lawsuits seeking compensation for:
- Medical expenses related to the injuries
- Lost wages or future earning potential
- Pain and suffering
- Emotional distress
- Long-term disability or reduced quality of life
In cases involving egregious misconduct, punitive damages may also be pursued.
Is There a Class Action or MDL Depo-Provera Lawsuit?
On February 7, 2025, the Judicial Panel on Multidistrict Litigation centralized and transferred the Depo-Provera (Depot Medroxyprogesterone Acetate) Products Liability Litigation, MDL No. 3140 in the Northern District of Florida before Judge M. Casey Rodgers.
At Constant Legal Group, we’re actively monitoring legal developments and preparing to support individuals harmed by Depo-Provera. If you’ve been affected, now is the time to explore your legal rights.
Do I Qualify to File a Depo-Provera Lawsuit?
You may qualify if:
- You received Depo-Provera injections for birth control
- You experienced serious health issues such as brain tumors
- You were not adequately warned of these risks
- Your injuries occurred within the statute of limitations for your state
Even if your injuries occurred years ago, there may be exceptions depending on when you learned of the link between your health condition and the drug. Our legal team can help evaluate your case.
Why Hire Constant Legal Group for Your Depo Provera Lawsuit?
Constant Legal Group is closely tracking the expanding legal action surrounding Depo-Provera lawsuits. If you or someone you love has suffered lasting harm—such as bone loss, severe depression, or neurological side effects—after using this contraceptive injection, we are prepared to take swift legal action on your behalf.
A Proven Record of Results
Our attorneys have successfully represented thousands of clients in complex drug and medical device cases. We’ve secured millions in compensation for people harmed by pharmaceutical companies that failed to put patient safety first. Attorney Ryan Cavanaugh has won high-stakes verdicts in mass tort cases, including an $8.2 million result against a chemical manufacturer. Constantine “Dean” Venizelos has decades of experience representing victims of asbestos and defective drugs and brings a background with the U.S. Department of Justice to every case he handles.
Strategic Leadership in High-Impact Cases
Our Depo-Provera attorneys have held leadership roles in major MDLs across the country. We understand the unique challenges of drug litigation and how to effectively pursue justice on a national scale. Whether you’re part of a growing mass tort or filing an individual lawsuit, we’re equipped with the experience, resources, and determination to take on major pharmaceutical companies, and win.
Get Started on a Depo-Provera Lawsuit Today
If you believe you’ve suffered harm after using Depo-Provera, don’t wait. Legal deadlines apply, and the sooner you act, the better positioned you are to build a strong case.
Reach out to Constant Legal Group today for a free, confidential case evaluation. Our compassionate and experienced attorneys are here to help you understand your rights, pursue justice, and recover the compensation you deserve.
Call us now or fill out our online form to get started.
A History of Depo-Provera Lawsuits and Cases
- 1990s–2000s bone health issues: as Depo-Provera (medroxyprogesterone acetate, or “DMPA”) became widely used, long-term users began reporting significant bone mineral density loss, osteoporosis, and even fractures
- FDA “black box” warning introduced in 2004: A mandatory warning was added to highlight the risks of prolonged bone loss, particularly after two years of continuous use.
- Cassandra Colville vs. Pharmacia & Upjohn (2008): A U.S. lawsuit focused on osteoporosis claims brought by a former Depo-Provera user.
- Canada class action, 2008–2021: A class action in Canada alleged Pfizer misrepresented bone-loss risks. In 2021, Pfizer settled, paying approximately CAD 1.9 million to the class and CAD 262,500 to insurers.
While effective for contraception, Depo-Provera has been linked to serious side effects like irreversible bone loss, depression, and fertility issues, especially with long-term use.
Yes, in 2004 the FDA added a black box warning to Depo-Provera’s label regarding the risk of significant and potentially irreversible bone density loss.
Lawsuits allege that the manufacturer failed to adequately warn patients about the risks, leaving many women with lasting health complications they didn’t expect.
Contact a qualified defective drug attorney at Constant Legal Group who can evaluate your case and guide you through the legal process with no upfront cost.
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